Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Flexibility decline contributes to similarity of past and future thinking in Alzheimer's disease

Abstract : A striking similarity has been suggested between past and future thinking in Alzheimer's Disease (AD), a similarity attributable to abnormalities in common modular cognitive functions and neuroanatomical substrates. This study extends this literature by identifying specific executive function deficits underlying past and future thinking in AD. Twenty-four participants with a clinical diagnosis of probable (mild) AD and 26 older controls generated past and future events and underwent tests of binding and the executive functions of flexibility, inhibition, and updating. AD patients showed similar autobiographical performances in past and future event generation, and so did control participants. In each group, the similarity of past and future thinking was predicted by flexibility. Furthermore, AD patients with low flexibility showed higher similarity of past and future thinking than those with high flexibility. These findings are interpreted in terms of involvement of the hippocampus and frontal lobes in future thinking. Deficits in these brain regions in AD are likely to compromise the ability to recombine episodic information into novel and flexible configurations as scenarios for the future. © 2015 Wiley Periodicals, Inc.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal.univ-lille.fr/hal-02460357
Contributeur : Lilloa Université de Lille <>
Soumis le : jeudi 30 janvier 2020 - 09:10:11
Dernière modification le : vendredi 31 janvier 2020 - 01:36:39

Lien texte intégral

Identifiants

Collections

Citation

Mohamad El Haj, Pascal Antoine, Dimitrios Kapogiannis. Flexibility decline contributes to similarity of past and future thinking in Alzheimer's disease. Hippocampus, 2015, Hippocampus, 25 (11), pp.1447-1455. ⟨10.1002/hipo.22465⟩. ⟨hal-02460357⟩

Partager

Métriques

Consultations de la notice

67