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Article Dans Une Revue Hippocampus Année : 2015

Flexibility decline contributes to similarity of past and future thinking in Alzheimer's disease

Résumé

A striking similarity has been suggested between past and future thinking in Alzheimer's Disease (AD), a similarity attributable to abnormalities in common modular cognitive functions and neuroanatomical substrates. This study extends this literature by identifying specific executive function deficits underlying past and future thinking in AD. Twenty-four participants with a clinical diagnosis of probable (mild) AD and 26 older controls generated past and future events and underwent tests of binding and the executive functions of flexibility, inhibition, and updating. AD patients showed similar autobiographical performances in past and future event generation, and so did control participants. In each group, the similarity of past and future thinking was predicted by flexibility. Furthermore, AD patients with low flexibility showed higher similarity of past and future thinking than those with high flexibility. These findings are interpreted in terms of involvement of the hippocampus and frontal lobes in future thinking. Deficits in these brain regions in AD are likely to compromise the ability to recombine episodic information into novel and flexible configurations as scenarios for the future. © 2015 Wiley Periodicals, Inc.

Dates et versions

hal-02460357 , version 1 (30-01-2020)

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Mohamad El Haj, Pascal Antoine, Dimitrios Kapogiannis. Flexibility decline contributes to similarity of past and future thinking in Alzheimer's disease. Hippocampus, 2015, Hippocampus, 25 (11), pp.1447-1455. ⟨10.1002/hipo.22465⟩. ⟨hal-02460357⟩
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