Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target

Michele Bastide 1 Thavarak Ouk 1 F. Plaisier 1 Olivier Petrault 1, 2 Svorad Stolc 3 Regis Bordet 1
1 Université de Lille
2 Université Lille 2 - Faculté de Médecine
3 SAS - Slovak Academy of Sciences
Abstract : Ischemic stroke induces drastic alterations of the functions of the neurogliovascular unit with dramatic consequences on the well-being of the patients in terms of cognitive and motor handicap. Nowadays, only very few therapeutics are available as a treatment of ischemic stroke. Ischemia is a multifactorial pathology involving different cerebral cellular components such as neurons, astrocytes and vessels working as a functional unit. Recent experimental strategy investigation involving different agents with antioxidant properties (dt-BC, stobadine) or pleiotropic effects (lipopolysaccharide, LPS) has been developed to evaluate whether the vascular wall could be considered as a potential target in neuroprotection concept.
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https://hal.univ-lille.fr/hal-02477189
Contributeur : Lilloa Université de Lille <>
Soumis le : jeudi 13 février 2020 - 11:26:26
Dernière modification le : jeudi 13 février 2020 - 11:26:28

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Michele Bastide, Thavarak Ouk, F. Plaisier, Olivier Petrault, Svorad Stolc, et al.. Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target. Psychoneuroendocrinology, Elsevier, 2007, Psychoneuroendocrinology, 32 (Suppl 1), pp.S36-S39. ⟨10.1016/j.psyneuen.2007.03.015⟩. ⟨hal-02477189⟩

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