Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

O-acetylated Gangliosides as Targets for Cancer Immunotherapy

Abstract : O-acetylation of sialic acid residues is one of the main modifications of gangliosides, and modulates ganglioside functions. O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities. CAS1 Domain-Containing Protein 1 (CASD1) is the only human sialyl-O-acetyltransferases (SOAT) described until now. O-acetylated ganglioside species are mainly expressed during embryonic development and in the central nervous system in healthy adults, but are re-expressed during cancer development and are considered as markers of cancers of neuroectodermal origin. However, the specific biological roles of O-acetylated gangliosides in developing and malignant tissues have not been extensively studied, mostly because of the requirement of specific approaches and tools for sample preparation and analysis. In this review, we summarize our current knowledge of ganglioside biosynthesis and expression in normal and pathological conditions, of ganglioside O-acetylation analysis and expression in cancers, and of the possible use of O-acetylated gangliosides as targets for cancer immunotherapy.
Liste complète des métadonnées
Contributeur : LillOA Université de Lille Connectez-vous pour contacter le contributeur
Soumis le : mercredi 24 mars 2021 - 10:39:59
Dernière modification le : mercredi 23 mars 2022 - 15:51:29


Fichiers éditeurs autorisés sur une archive ouverte


Distributed under a Creative Commons Paternité 4.0 International License




Sumeyye Cavdarli, Philippe Delannoy, Sophie Groux. O-acetylated Gangliosides as Targets for Cancer Immunotherapy. Cells, MDPI, 2020, 9 (3), pp.741. ⟨10.3390/cells9030741⟩. ⟨hal-03179134⟩



Consultations de la notice


Téléchargements de fichiers