The growth of X-in-the-Loop (XiL) testing has been accompanied by a rapid growth in tools tailored for testing. While this increases the accessibility of tools for various specific applications, using multiple model and testing softwares can introduce compatibility issues when performing tests in the integration stage. This article provides a demonstration framework of a flexible Hardware-in-the-Loop (HiL) interface utilizing both Typhoon HIL and SIEMENS Amesim software and hardware for full vehicle emulation. First demonstrations of these HiL interfaces for a Plug-in Hybrid Electric Vehicle (PHEV) are shown. Flexible HiL interfaces such as these represent a much easier way to integrate full vehicle models within existing vehicle development frameworks.