The perception of a manipulable object is known to evoke motor representations associated with potential interactions with the visual object. To date, much of the research on affordance evocation has used simple situations involving an object presented in isolation. However, natural perceptual environments typically consist of multiple objects that evoke multiple affordances, which may be similar or dissimilar. Here, we investigated the consequences of multiple affordance evocation on the processing of a target object among distractors and questioned the factors that influence affordance selection. Two complementary experiments using behavioral and neurophysiological measures were designed to address these issues. In both experiments, participants had to select a target object in 3D scenes containing object pairs. The objects could evoke similar or dissimilar affordances and could be thematically related (e.g., key-lock) or unrelated. Behavioral results revealed slower responses to the target object when the distractor evoked similar compared to dissimilar affordances. The cost of similar affordances observed for unrelated objects disappeared when objects were thematically related. At the neurophysiological level, the evolution of µ-rhythm desynchronization follows a similar pattern of results. A reduction of µ-rhythm desynchronization was only observed when participants had to select the object among unrelated distractors that evoked similar affordance. These findings support recent predictions of automatic inhibition of distractor affordances during object selection and provide additional evidence for context-dependent affordance activation in naturalistic scenes.